good fasting ppactice on malondialdehyde and 8-hydroxydeoxyguanosine (ahead of publication)
نویسندگان
چکیده
background & objectives: good fasting practice is not only refraining from foods and drinks in a period of time, but should encompass several important factors including unexcessive eating habit during ifthor. understanding the effect of fasting accompanied by calorie restriction (cr) in oxidative stress indicators, malondialdehyde (mda) and 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxodg), that are commonly increased in degenerative diseases. methods: 24 male sprague dawley (sd) rats were divided into four groups. groups 1-3: fasting with total calorie consumption per day 70% (p70), 100% (p100), and 140% (p140) respectively. meanwhile, all rats in group 4 (al100) were on ad libitum diet with 100% total calories consumption. mda serum level was measured using tbars assay, whereas urinary 8-oxodg level was measured using elisa assay. randomized post-test only control group design was applied and the data were analyzed using one-way anova followed by post-hoc lsd with a significant level of p < 0.05. results: the lowest mda level was on group p70 (0.770 nmol/ml) followed group p100 (1.298 nmol/ml), group al100 (2.418 nmol/ml), and group p140 (3.924 nmol/ml) respectively. meanwhile, the lowest 8-oxodg level was on group al100 (2.580 ng/ml), followed by group p140 (2.660 ng/ml), group p100 (3.260 ng/ml), and group p70. the statistical analysis for both variables using one-way anova showed that p = 0.000 (p < 0.05). pearson’s correlation coefficient of mda and 8-oxodg levels indicated a strong negative linear relationship between variables. interpretation & conclusion: good fasting practice decreases mda level, but conversely increases 8-oxodg level.
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عنوان ژورنال:
journal of fasting and healthجلد ۴، شماره ۳، صفحات ۱۰۶-۱۱۰
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